N′-[(E)-4-Methoxybenzylidene]-2-(5-methoxy-2-methyl-1H-indol-3-yl)acetohydrazide
نویسندگان
چکیده
The conformation adopted by the title compound, C20H21N3O3, in the crystal is 'J'-shaped and appears to be at least partially directed by a weak intra-molecular C-H⋯N hydrogen bond. In the crystal, mol-ecules are linked by N-H⋯O hydrogen bonds, forming dimers with R 2 (2)(8) motifs. Furthermore, these dimers connect to each other via C-H⋯O and N-H⋯O hydrogen bonds to form a three-dimensional network.
منابع مشابه
N′-[(E)-4-(Dimethylamino)benzylidene]-2-(5-methoxy-2-methyl-1H-indol-3-yl)acetohydrazide
In the title compound, C(21)H(24)N(4)O(2), inversion-related mol-ecules are linked into dimers through pairs of N-H⋯O hydrogen bonds, which generate R(2) (2)(8) motifs. As well as dimer formation, an additional N-H⋯O hydrogen bond and two C-H⋯π contacts, involving H atoms from the phenyl ring and the pyrrole and benzene rings of the indole system, generate a three-dimensional network.
متن کامل2-(5-Methoxy-2-methyl-1H-indol-3-yl)-N′-[(1E,2E)-3-phenylprop-2-en-1-ylidene]acetohydrazide
The title compound, C21H21N3O2, adopts a J-shaped conformation which appears to be at least partially directed by a weak intra-molecular C-H⋯N hydrogen bond. In the crystal, mol-ecules are linked by N-H⋯O hydrogen bonds into R 2 (2)(8) and R 2 (2)(14) cyclic dimers, which form a chain running parallel to the b axis.
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A simple and efficient method for the synthesis of 3-indolyl-3-hydroxy oxindoles and unsymmetrical 3,3-di(indolyl)indolin-2-ones using microwave irradiation without catalyst and solvent is described. A series of 3-indolyl-3-hydroxy oxindoles and unsymmetrical 3,3-di(indolyl)indolin-2ones have been synthesized in very short reaction times of 5 and 10 minutes and in yields ranging from 31% to 98%...
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متن کاملSynthesis of {3-(2-dimethylamino-ethy1)-2-[3-(2- dimethylaminoethyl)-1H-indol-5-ylmethyl]-1H-indol-5-yl}-N- methyl-methanesulfonamide, the main Sumatriptan impurity
An improved multistep synthesis of {3-(2-dimethylamino-ethy1)-2-[3-(2dimethylaminoethyl)-1H-indol-5-ylmethyl]-1H-indol-5-yl}-N-methyl-methanesulfonamide, the main Sumatriptan impurity, is described, as a model for other related triptan derivatives.
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عنوان ژورنال:
دوره 69 شماره
صفحات -
تاریخ انتشار 2013